THIS POST WILL CONSIST OF ONE ACT: StvMg suggested in the comments to the Phil Collins post that the This American Life piece to which Collins contributed, "The Breakup," was the best in show history. And I realized, hey: there's a list we've constructed yet! Let's get to it.
(And, by the way, I do have a concept for another round of Humiliation.)
My nominees are a mix of the political and the more entertaining -- Giant Pool of Money and Harold for the former, #1 Party School, The Middle of Nowhere, and Tough Room for the latter. Your mileage will assuredly vary.